![]() To illustrate this point, I will apply the criticisms of SV-AUC state by Engelsmen et al. All analytical methods are open to the same criticisms that are based on a perception of the community of scientists and instrument manufacturers involved in the instrument design and use. PMID: 20972611 PMCID: PMC3063870.) This list of disadvantages has nothing specifically to do with SV-AUC as a scientific method. ![]() Strategies for the assessment of protein aggregates in pharmaceutical biotech product development. centerpieces) complex data analysis time consuming expensive instrumentation expert personnel needed.” (den Engelsman J, Garidel P, Smulders R, Koll H, Smith B, Bassarab S, Seidl A, Hainzl O, Jiskoot W. ![]() published a paper entitled “Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development.” In this paper, the “disadvantages” of sedimentation velocity analytical ultracentrifugation experiments for quantifying aggregates in protein samples are summarized in a table: “Strongly dependent on quality of instrument components (e.g. ![]()
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